國立清華大學講座教授 (Tsing Hua Professor of Life Sciences)

Signal Transduction on Cancer Research

On the basis of molecular, cellular, animal, clinicopathological, epidemiological, psychosocial, and human studies combined and interplayed together, the most fatal, potential and promising multisubstrate/multifunctional signal transducing molecules, signal transduction pathways and signaling networks will be selected, identified, characterized and demonstrated for early diagnosis, disease monitoring, drug screening and new therapeutic strategies of various types of human cancers including pancreatic cancer, hepatoma, colorectal cancer, ovarian cancer, cervical cancer, breast cancer, lung cancer and leukemia.

以訊號傳遞的眼光，利用多功能多受質訊號傳遞分子、細胞及動物 為模式，並結合臨床中西醫、病理、流行病學及社會心理學，針對臨床醫師及病人需求， 以多角度、多方面去建立各種癌病早期診斷、早期治療的新方法及新策略。

1.  Fu HH, Yang SD. Suppression of proline-directed protein kinase F_A inhibits the malignant growth of human pancreatic ductal adenocarcinoma. (2004) (in press)

2.  Chung YC, Chang KJ, Yang CC, Lai MT, Hsu CP, Hsueh SF, Peng CC, Fu HH, Chang YF, Yang SD. Association of proline-directed protein kinase F_A with tumorigenesis, invasion, and poor prognosis of human colon carcinoma. Cancer 95: 1840-1847. (2002).

3.  Hsu CP, Yang CC, Hsueh SF, Peng CC, Fu HH, Yang SD. Suppression of proline-directed protein kinase F_A potentiates apoptotic induction and greatly enhances chemosensitivity in human acute lymphoblastic leukemia cells. Cancer 92: 1753-1758. (2001).

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